Library earns high marks

The team that works together earns together.

Vesicular transport earns a Nobel.

The field of intracellular traffic is celebrating the awarding of the 2013 Nobel Prize in Physiology or Medicine to three of its most distinguished scientists--James Rothman, Randy Schekman, and Thomas Südhof--for their discoveries on the molecular mechanisms of vesicular transport. Their outstanding achievements serve as inspiration for the next generation of scientists to continue the task of...

What re-enactment earns us.

Evidence from both behavioural and brain studies suggests that perception of actions and their outcomes may induce (overt or covert) production of related actions in perceivers. Three views of the proper function of such re-enactment have been suggested: imitation, identification, and anticipation. Here I propose that the proper function of re-enactment is to subserve anticipation of upcoming a...

Risk Choice under High - Water Marks

I solve in closed form for the optimal dynamic risk choice of a fund manager who is compensated with a high-water mark contract. The optimal risk choice depends on the ratio of the fund’s assets under management to its high-water mark. If the manager’s outside option value is low, investors’ termination policy is strict, or management fees are high, then negative returns induce the manager into...

High throughput docking for library design and library prioritization.

The prioritization of the screening of combinatorial libraries is an extremely important task for the rapid identification of tight binding ligands and ultimately pharmaceutical compounds. When structural information for the target is available, molecular docking is an approach that can be used for prioritization. Here, we present the initial validation of a new rapid approach to molecular dock...